Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via modulating SIRT1/FOXO3a and HO-1/ferritin pathways: A biochemical, histopathological and computational approaches

Key Points

• Ayanin significantly reduces hepatotoxicity caused by barium sulphate nanoparticles.
• The intervention demonstrated a notable modulation of SIRT1 and FOXO3a pathways, crucial for cellular survival.
• Biochemical, histopathological, and computational methods were employed to assess Ayanin's effects.
• This analysis highlights Ayanin's potential as a therapeutic agent against nanoparticle-induced liver damage.