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The role of lactate on arthritis-associated cells: physiology, pathology, and therapeutic strategies | Synapse
March 3, 2026
Open Access
The role of lactate on arthritis-associated cells: physiology, pathology, and therapeutic strategies
JC
Jinhao Chen
Zhejiang University Medical College Affiliated Stomatological Hospital
YW
Ying Wang
Fujian Normal University
RS
Ruifeng Song
Zhejiang University Medical College Affiliated Stomatological Hospital
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Key Points
Lactate influences inflammation in arthritis-associated cells, affecting disease progression.
Key evidence indicates that elevated lactate levels correlate with increased immune response in arthritis models.
Assessment using immune cell analysis highlights lactate's effects on cell function and pathology in arthritis.
Understanding the role of lactate may enable new therapeutic strategies for managing arthritis.
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Chen et al. (Wed,) studied this question.
synapsesocial.com/papers/69a76088c6e9836116a2d5e8
https://doi.org/https://doi.org/10.1007/s00018-025-06073-1