Optimising protamine dosing for heparin reversal after cardiopulmonary bypass: a population pharmacokinetic–pharmacodynamic study

Key Points

• Protamine dosing can effectively reverse heparin after cardiopulmonary bypass, improving safety.
• The analysis utilized population pharmacokinetic and pharmacodynamic models to establish optimal dosing.
• Involves detailed assessments of drug interactions and effects in a diverse patient population.
• Results may call for more personalized approaches to heparin reversal in clinical settings.