TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability

Key Points

• Inhibition of mRNA accumulation occurs through TDP-43's effect on mRNA stability, leading to altered gene expression.
• Significant decrease in mRNA levels were observed when TDP-43 was present, affecting cellular communication.
• Analysis shows that TDP-43 directly interacts with mRNA, modulating stability in neurites, particularly in neuronal cells.
• These findings highlight the potential implications of TDP-43 on neuronal health and disease progression.