The effects of dutasteride and tamsulosin, alone or in association, in the kidney morphology: experimental study in rats

Key Points

• This research aims to evaluate the impact of dutasteride and tamsulosin on kidney morphology in a rodent model.
• Conducted an experimental study using rats
• Administered dutasteride and tamsulosin separately and in combination
• Assessed kidney morphology and nephron integrity
• Dutasteride led to more severe kidney damage than tamsulosin
• Combined treatment resulted in significant nephron losses
• Isolated tamsulosin caused less renal modifications compared to dutasteride