Effect of flunixin meglumine on the pharmacokinetics of enrofloxacin and marbofloxacin in preweaning calves

Key Points

• The aim is to evaluate how flunixin meglumine affects the pharmacokinetics of enrofloxacin and marbofloxacin in preweaning calves.
• Administer flunixin meglumine alongside enrofloxacin and marbofloxacin to preweaning calves.
• Measure and compare drug elimination rates and efficacy.
• Analyze the pharmacokinetic profiles of both antibiotics after treatment.
• Flunixin significantly prolongs the elimination time of enrofloxacin and marbofloxacin.
• No compromise in estimated efficacy of the antibiotics observed.
• Specific optimization may be necessary for targeting certain respiratory disease pathogens.