Preoperative First-line Amlodipine in Pheochromocytoma/Paraganglioma: Perioperative Haemodynamic Instability and Its Predictors

Key Points

• This research aims to evaluate the effectiveness of amlodipine in preventing hemodynamic instability in patients with pheochromocytoma and paraganglioma.
• Administered amlodipine as a first-line treatment preoperatively.
• Monitored plasma levels of metanephrine and normetanephrine.
• Assessed hemodynamic stability during surgery.
• Amlodipine significantly reduced incidence of intraoperative hypertension.
• Elevated plasma free metanephrine levels correlated with higher rates of intraoperative hypertension.
• Postoperative hypotension was linked to increased levels of normetanephrine.