June 24, 2022Open Access

Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

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Abstract

Paired syngeneic models help unravel the interplay between CAF and tumor immune evasion, highlighting the benefits of targeting fibroblast subpopulations to improve clinical responses to immunotherapy.

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Jenkins et al. (Fri,) studied this question.

www.synapsesocial.com/papers/69d6c3c5a0177bf533ed8dfd — DOI: https://doi.org/10.1158/0008-5472.can-21-4141

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Authors

Liam Jenkins

Ute Jungwirth

Alexandra Avgustinova

Journals

Cancer Research

Actions

Institutions

University of Bath

Breast Cancer Now

AstraZeneca (Singapore)

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Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

Key Points

Abstract

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Discussion

Cite this study

Also consider

Authors

Journals

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Institutions

References and Citations

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