A Case Report of the "Pathological Triad": Infection-Induced Cold Agglutination with Hemolytic Anemia

Key Points

• The aim is to establish protocols for diagnosing infection-induced cold agglutination and hemolytic anemia.
• Testing for Mycoplasma pneumoniae in patients with unexplained anemia after respiratory infection.
• Applying thermal correction to blood samples when MCHC results are inconsistent.
• Monitoring for hemolysis for at least two weeks post Mycoplasma pneumoniae IgM detection.
• Three evidence-based protocols were established for frontline clinical practice.
• Recommendation to test for Mycoplasma pneumoniae based on anemia post-infection.
• Importance of thermal correction in blood sample analysis was highlighted.