Neutrophil Extracellular Traps Aggravate Injury in Complement-Mediated Thrombotic Microangiopathy

Key Points

• The central aim is to understand how neutrophil extracellular traps (NETs) contribute to organ injury in complement-mediated thrombotic microangiopathy (TMA).
• Assessment of NETs biomarkers in patients with complement-mediated TMA.
• Evaluation of CD59 shedding from human renal glomerular endothelial cells (HRGECs).
• Analysis of the relationship between NETs and complement activation as well as coagulation processes.
• Increased levels of NETs biomarkers were observed in cases of complement-mediated TMA.
• NETs contributed to organ injury by shedding CD59 from HRGECs, which enhanced complement activation.
• NETs were linked to the activation of coagulation pathways.

Abstract