Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

Key Points

• To evaluate how thinning of the inner retinal layer affects visual function in individuals with OPA1-related autosomal dominant optic atrophy (ADOA).
• Analyzed the relationship between inner retinal layer thickness and visual acuity (VA) in ADOA patients.
• Measured mGCL (macular ganglion cell layer) thickness in the PMB (parafoveal macular bag) subfield.
• Considered patient age and genetic variant types as influencing factors.
• Significant association found between inner retinal layer thickness and severity of visual acuity and central scotoma.
• mGCL thickness was a key predictor of visual function changes.
• Worse visual outcomes noted in heterozygous individuals with missense variants in OPA1.