Chronic-use drugs were the most common triggers for prescribing cascades, with 84 different adverse drug reactions identified across 165 primary studies.
Systematic Review
Patients, especially older adults, experiencing prescribing cascades and polypharmacy
Prescribing cascades (PCs)
Prescribing cascades are a significant driver of inappropriate polypharmacy, highlighting the need for standardized definitions and clinical prevention strategies.
PCs are an underrecognized driver of inappropriate polypharmacy, especially in older adults, yet current evidence is largely retrospective and heterogeneous. By consolidating available data, our work provides a valuable reference tool for clinicians and researchers. Future efforts should focus on establishing standardized definitions and developing clinical strategies to prevent inappropriate PC use.
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Massimo Carollo
Salvatore Crisafulli
Marta Zerio
Drugs & Aging
Erasmus MC
University of Verona
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Carollo et al. (Wed,) conducted a systematic review in Prescribing cascades and adverse drug reactions. Chronic-use medications (e.g., antipsychotics, anxiolytics, lipid-modifying agents, antihypertensives) was evaluated on Identification of medications and adverse drug reactions (ADRs) involved in prescribing cascades. Chronic-use drugs were the most common triggers for prescribing cascades, with 84 different adverse drug reactions identified across 165 primary studies.
www.synapsesocial.com/papers/69d8967d6c1944d70ce07f1e — DOI: https://doi.org/10.1007/s40266-026-01295-9