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The Histopathological Features of Secondary Syphilis: A Case Series | Synapse

April 10, 2026

The Histopathological Features of Secondary Syphilis: A Case Series

Key Points

The aim is to identify the diverse histopathological features associated with secondary syphilis.
Analysis of histological samples from patients diagnosed with secondary syphilis
Examination of epidermal and dermal patterns of inflammatory cells
Comparison with typical presentations of the disease
Observed a range of inflammatory cells beyond the typical lichenoid infiltrate
Identified various reaction patterns in the epidermis and dermis
Highlighting the need to consider secondary syphilis in differential diagnoses of inflammatory diseases

Abstract

Although secondary syphilis is typically thought to have elongated rete with a lichenoid infiltrate with plasma cells, there is a broad range of possible epidermal and dermal inflammatory cells and reaction patterns. Secondary syphilis should be considered for a wide spectrum of inflammatory disease.

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Cite this study

Hanly et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69d8968f6c1944d70ce08059 — DOI: https://doi.org/10.1111/cup.70113

Authors

A

Ailish Hanly

G

Gauri Panse

P

Peggy Myung

Journals

Journal of Cutaneous Pathology

Actions

Institutions

Yale University

References and Citations

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