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Somatic ERCC2 mutations correlate with complete response to cisplatin-based chemosensitivity in muscle-invasive urothelial carcinoma, and clinically identified mutations lead to cisplatin sensitivity in vitro. Nucleotide excision repair pathway defects may drive exceptional response to conventional chemotherapy.
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Allen et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69da24d8387cf70698686416 — DOI: https://doi.org/10.1158/2159-8290.cd-14-0623
Eliezer M. Van Allen
Kent W. Mouw
Philip Kim
Cancer Discovery
Cornell University
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