Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial | Synapse
April 15, 2026
Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial
Key Points
To evaluate the effects of mepolizumab on airway physiology outcomes following functional endoscopic sinus surgery in adults with CRSwNP.
Conducted a randomised controlled trial.
Administered mepolizumab to patients undergoing functional endoscopic sinus surgery.
Assessed airway hyperresponsiveness through bronchial challenges.
Airway hyperresponsiveness significantly improved after treatment with mepolizumab.
The improvement was particularly evident during indirect bronchial challenges.
Abstract
Summary Airway hyperresponsiveness improved after mepolizumab, particularly for indirect bronchial challenge. Analyses were exploratory and not pre‐specified in the randomised trial protocol.