Effect of androgens on retinal microvasculature in prepubertal girls with isolated premature pubarche

Key Points

• The aim is to investigate the effects of androgens on retinal microvasculature in prepubertal girls with isolated premature pubarche.
• Comparison of prepubertal girls with isolated premature pubarche to a control group.
• Assessment of retinal nerve fiber layer thickness (RNFL) and vessel density (VD) using optical coherence tomography (OCT) and OCT angiography (OCTA).
• Thickening of RNFL observed in prepubertal girls with isolated premature pubarche.
• Increased VD in the macula and optic disc regions detected compared to the control group.
• Noninvasive detection of early microvascular changes established.

Abstract