What is the clinical evidence from this study?

Study design: Cohort. Population: Heart failure with monoclonal gammopathies (n=187). Intervention: Left ventricular posterior wall (LVPW) thickness vs. Difference in serum free light-chain (dFLC) levels. Primary outcome: Diagnosis of cardiac light-chain amyloidosis (CA-AL) (OR 1.71, 95% CI 1.40-2.10, p=<0.001).

What question did this study set out to answer?

The research aims to determine how LVPW thickness relates to diagnosing cardiac amyloidosis in heart failure patients with monoclonal gammopathies.

April 15, 2026Open Access

Left ventricular posterior wall thickness independently predicts the possibility of light-chain cardiac amyloidosis in hospitalized heart failure patients with monoclonal gammopathies

Q: What are the key findings of this study?

Left ventricular posterior wall thickness independently predicted cardiac light-chain amyloidosis with an area under the curve of 0.798 in heart failure patients with monoclonal gammopathies.

Q: What question did this study set out to answer?

The research aims to determine how LVPW thickness relates to diagnosing cardiac amyloidosis in heart failure patients with monoclonal gammopathies.

Key Result

Left ventricular posterior wall thickness independently predicted cardiac light-chain amyloidosis with an area under the curve of 0.798 in heart failure patients with monoclonal gammopathies.

Key Points

The research aims to determine how LVPW thickness relates to diagnosing cardiac amyloidosis in heart failure patients with monoclonal gammopathies.
Analyzed hospitalized heart failure patients diagnosed with monoclonal gammopathies.
Measured left ventricular posterior wall thickness.
Evaluated the relationship between LVPW thickness and the likelihood of cardiac amyloidosis.
Higher left ventricular posterior wall thickness was associated with a greater likelihood of cardiac amyloidosis.
LVPW thickness serves as a significant predictor for diagnosing CA-AL in these patients.

Study Design

Type

Cohort

Multicenter

Structured PICO

Does left ventricular posterior wall thickness predict light-chain cardiac amyloidosis in hospitalized heart failure patients with monoclonal gammopathies?

Population

Hospitalized heart failure patients with monoclonal gammopathies

Intervention

Left ventricular posterior wall (LVPW) thickness assessment

Outcome

Prédiction/diagnostic de l'amylose cardiaque à chaînes légères (CA-AL)

Left ventricular posterior wall thickness is an effective predictor for diagnosing light-chain cardiac amyloidosis in hospitalized heart failure patients with monoclonal gammopathies.

Limitations

Retrospective nature fails to determine causal and temporal relationships between LVPW thickness and CA-AL
Limited number of CA-AL patients included in the study
Types of disease in the control group were overly simplified, lacking patients with other forms of amyloidosis such as ATTR

Abstract

These findings suggest that LVPW thickness effectively predicts CA-AL in hospitalized heart failure patients with monoclonal gammopathies, thereby providing valuable insights into the diagnostic process for CA-AL.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Bokang Yu

Weipeng Zhao

Zheng Wei

Journals

Cardiology Journal

Actions

Institutions

Fudan University

Sun Yat-sen University

Xiamen University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Yu et al. (Thu,) ont mené une cohorte sur l'insuffisance cardiaque avec gammapathies monoclonales (n=187). L'épaisseur de la paroi postérieure du ventricule gauche (LVPW) par rapport à la différence des niveaux de chaînes légères libres sériques (dFLC) a été évaluée pour le diagnostic de l'amylose cardiaque à chaînes légères (CA-AL) (OR 1,71, IC 95 % 1,40-2,10, p=<0,001). L'épaisseur de la paroi postérieure du ventricule gauche a prédit indépendamment l'amylose cardiaque à chaînes légères avec une aire sous la courbe de 0,798 chez les patients insuffisants cardiaques présentant des gammapathies monoclonales.

www.synapsesocial.com/papers/69df2c2fe4eeef8a2a6b1370 — DOI: https://doi.org/10.5603/cj.104037

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Left ventricular posterior wall thickness independently predicts the possibility of light-chain cardiac amyloidosis in hospitalized heart failure patients with monoclonal gammopathies

Key Result

Key Points

Study Design

Structured PICO

Limitations

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider