Response by Szczeklik et al to Letter Regarding Article, “Ivabradine in Patients Undergoing Noncardiac Surgery: A Randomized Controlled Trial”

“Ivabradine did not reduce the risk of MINS in patients undergoing noncardiac surgery. Heart-rate lowering was modest and the possible higher MINS incidence in patients with known coronary artery disease is contrary to our original hypothesis. Further research is needed to establish a method to safely control the heart's stress associated with noncardiac surgery.”