To evaluate the antifungal activity of thiazole compounds against Fusarium sacchari, which causes Pokkah boeng disease in sugarcane.
Evaluated the antifungal metabolites cystothiazole A and melithiazol F against Fusarium sacchari.
Assessed effects on growth, spore germination, and cell membrane integrity of the pathogen.
Cystothiazole A and melithiazol F significantly inhibited Fusarium sacchari growth and spore germination.
Disruption of cell membrane integrity was observed with both thiazole compounds.
Abstract
The thiazole compounds cystothiazole A (7) and melithiazol F (9) potently inhibited Fusarium sacchari by suppressing its growth and spore germination and disrupting cell membrane integrity.