Supplementary Figure 2 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1+ tumor-associated macrophages contribute to CD8+ T-cell dysfunction in clear-cell renal cell carcinoma.
• The presence of SPP1+ TAMs is linked to resistance against immunotherapy, posing challenges for treatment outcomes.
• Validation of the SPP1+ signature supports its significance as a target for enhancing immunotherapy efficacy.
• Understanding TAMs' role is critical for developing strategies to overcome immune resistance mechanisms.

Abstract