What question did this study set out to answer?

This study aims to evaluate techniques for elemental mapping in biological samples using high-resolution methods.

January 18, 2026Journal of Analytical Atomic Spectrometry0 citationsOpen Access

Substrate and standard evaluation for correlative elemental mapping of biological samples by X-ray fluorescence microscopy and laser ablation ICP-MS

DZDavid Z. Zee SASoo Hyun Ahn ACAndrew M. Crawford

Key Points

This study aims to evaluate techniques for elemental mapping in biological samples using high-resolution methods.
Utilized x-ray fluorescence microscopy for detailed elemental mapping of samples.
Employed laser ablation ICP-MS for precise elemental analysis.
Conducted comparative analysis of the two techniques.
Assessed the effectiveness of substrate materials for both methods.
Demonstrated superior sensitivity and resolution in elemental mapping with x-ray fluorescence microscopy.
Laser ablation ICP-MS provided complementary data, enhancing the overall understanding of sample composition.

Abstract

Analytical techniques that offer accurate, sensitive, and high-resolution elemental mapping have significantly advanced our understanding of the role of inorganic chemistry in vital biological processes.

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