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This research aims to explore how microrna-loaded nanocapsules can influence macrophage polarization to enhance bone repair.

March 1, 2026Journal of Materials Chemistry B0 citations

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MicroRNA Nanocapsules for Modulating Macrophage Polarization to Promote Bone Repair

XLXueping Li MZMing Zhang QZQi Zhan

Key Points

This research aims to explore how microrna-loaded nanocapsules can influence macrophage polarization to enhance bone repair.
Utilized microrna-containing nanocapsules to target macrophages
Assessed macrophage polarization towards M2 phenotype
Evaluated the effects on bone repair in experimental models
Nanocapsules effectively shifted macrophages from M1 to M2 phenotype
Improved bone healing observed with M2-polarized macrophages
Demonstrated significant enhancement in bone repair markers

Abstract

Macrophages, highly versatile immune cells, play essential roles in various pathological conditions. The ability to modulate macrophage phenotypes presents a promising therapeutic strategy. Rapidly transitioning macrophages from the pro-inflammatory M1...

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MicroRNA Nanocapsules for Modulating Macrophage Polarization to Promote Bone Repair

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