Ginkgetin attenuates oxidative stress–induced apoptosis and osteoarthritis progression via the PI3K/Akt signaling pathway–mediated upregulation of Bcl-2

Key Points

• Ginkgetin reduces oxidative stress and apoptosis in osteoarthritis, which may slow disease progression.
• Key evidence shows upregulation of Bcl-2 correlates with improved outcomes in oxidative stress conditions.
• Assessment using the PI3K/Akt signaling pathway indicates a mechanism for ginkgetin's effects on apoptosis.
• Findings suggest ginkgetin may serve as a therapeutic agent, but further studies are required to confirm results.