Effect of norepinephrine versus vasopressin weaning on incidence of hypotension in septic shock patients: a systematic review and meta-analysis

Key Points

• No differences were observed in hypotension incidence when weaning with norepinephrine or vasopressin, leading to uncertainty in clinical practice.
• Hypotension rates remained consistent between both treatments, indicating a possible uniform effect in septic shock management.
• Systematic review and meta-analysis of existing data revealed notable variability among included studies.
• Findings suggest careful interpretation is necessary due to high heterogeneity across reported studies.