Impact of total gastrectomy plus perioperative PD-1 inhibitors on survival in locally advanced gastric cancer

Key Points

• Long-term survival improved significantly with the combination of total gastrectomy and PD-1 inhibitors.
• The combination achieved enhanced pathological response rates compared to traditional methods or treatments alone.
• Assessment using the perioperative sintilimab + XELOX regimen demonstrated a manageable safety profile.
• This indicates a promising treatment avenue but calls for further validation in larger cohorts.