Chronic (180-day) and sub-chronic (90-Day) oral toxicity studies of a novel polyethyleneglycol (PEG)-carbohydrate-lipid conjugate in Wistar rats and beagle dogs

Key Points

• Chronic and sub-chronic toxicity studies showed no major adverse effects in Wistar rats and beagle dogs.
• The assessment included a 180-day chronic study and a 90-day sub-chronic study involving various dosages.
• Assessment of the oral toxicity of a polyethyleneglycol-carbohydrate-lipid conjugate was conducted across both species.
• Findings may support further development and testing of this novel conjugate for therapeutic applications.