ESRP1 drives epithelial-mesenchymal transition by activating EPAC-RAP1A signaling axis

Key Points

• Epithelial-mesenchymal transition is driven by ESRP1 upregulation in alveolar epithelial cells, revealing a key mechanism in disease progression.
• The analysis highlights that ESRP1 activates the Epac-Rap1a signaling axis, a critical pathway in this process.
• Using cellular models, we explored how ESRP1 influences EMT, providing insights into potential targets for intervention in IPF.
• Understanding ESRP1's role supports the development of new strategies to mitigate IPF progression, offering hope for treatment options.