HIV causes global B-cell dysregulation and restricts HBV-specific B-cell development in an incident HBV cohort

Key Points

• This research aims to investigate how HIV affects B-cell function and HBV-specific B-cell development.
• Analyzed a cohort of individuals with new HBV infections
• Assessed B-cell responses in relation to HIV status
• Used statistical methods to evaluate associations between HIV and B-cell development
• HIV infection was linked to significant B-cell dysregulation
• Development of HBV-specific B-cells was notably restricted in individuals with HIV
• Findings indicate a possible negative impact on immune response against HBV