Mitoxantrone was identified as a translation inhibitor targeting the bacterial ribosome with an IC50 of 14.10 mM, demonstrating a bacteriostatic effect comparable to Clindamycin.
A computational pipeline and in vitro validation successfully identified several small molecules, including Mitoxantrone, as inhibitors of bacterial protein synthesis.
A hierarchical VS pipeline to target the bacterial ribosome PTC and in vitro translation assays identified Mitoxantrone as a potent inhibitor of E. coli protein synthesis, and Plerixafor, Olcegepant, and Ziritaxestat as lead compounds.
Yuce et al. (Thu,) conducted a other in Bacterial infection (in vitro). Mitoxantrone vs. Clindamycin was evaluated on IC50 for translation inhibition. Mitoxantrone was identified as a translation inhibitor targeting the bacterial ribosome with an IC50 of 14.10 mM, demonstrating a bacteriostatic effect comparable to Clindamycin.