High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Samuels et al. (Mon,) studied this question.

www.synapsesocial.com/papers/69d8da67ade63f05b9bedb5b — DOI: https://doi.org/10.1126/science.1096502

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. Prevalence of somatic alterations in the colorectal cancer cell genome· 2002 · 179 citations
2. Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors· 1998 · 93 citations
3. PIK3CA is implicated as an oncogene in ovarian cancer· 1999 · 1,163 citations
4. Phosphatidylinositol-3-OH kinase direct target of Ras· 1994 · 1,935 citations
5. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC