Waning of measles immunity by 5 years of age following an accelerated two-dose measles vaccine schedule at 6 and 12 months in South African children: an observational cohort study | Synapse
April 15, 2026Open Access
Waning of measles immunity by 5 years of age following an accelerated two-dose measles vaccine schedule at 6 and 12 months in South African children: an observational cohort study
Key Points
To investigate the duration of measles immunity in South African children after receiving two doses of vaccine.
Conducted an observational cohort study
Assessed measles immunity in children at age five
Analyzed outcomes following an accelerated two-dose vaccine schedule
Significant waning of measles immunity observed by 5 years of age
Decreased antibody levels noted following the two-dose vaccine schedule
Findings suggest a potential need for booster vaccinations
Abstract
This study was funded in part by the South African Medical Research Council through its Division of Research Capacity Development under the Chan Soon-Shiong Family Foundation Scholarship Programme.