ANGPT2 /Tie2 Enhances H3K18la ‐Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain

Key Points

• This research aims to explore how ANGPT2/Tie2 induces M2 polarization of macrophages to promote endothelial cell growth in chronic ischemia.
• Examined the role of ANGPT2/Tie2 in macrophage polarization
• Assessed H3K18la's impact on M2 macrophage activation
• Evaluated endothelial cell proliferation in chronic ischemic conditions
• ANGPT2/Tie2 effectively induces M2 polarization of macrophages
• H3K18la is a key mediator in this polarization process
• Increased endothelial cell proliferation was observed in response to M2 macrophage activation