Neuroendocrine Mechanisms of the Stress Response and Its Morphofunctional Effects on Organism Systems

This research paper aims to scientifically and theoretically analyze the pathophysiological mechanisms of stressor agents on the human organism, specifically the morphofunctional transformations occurring in the neuroendocrine regulation, cardiovascular, and immune systems. The article elucidates the activation of the hypothalamic-pituitary-adrenal (HPA) axis during acute and chronic stress, as well as the destructive effects of catecholamine and glucocorticoid secretion on organ tissues within the framework of modern clinical and histological approaches. The research findings serve to understand the etiology of psychosomatic diseases, optimize the diagnostic process, and enhance the effectiveness of rehabilitative measures in preventive medicine.