Mp10-08 Sarcomatoid Dedifferentiation as a Predictor of Overall Mortality in Surgically Treated Metastatic Renal Cell Carcinoma

You have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) I (MP10)1 May 2024MP10-08 SARCOMATOID DEDIFFERENTIATION AS A PREDICTOR OF OVERALL MORTALITY IN SURGICALLY TREATED METASTATIC RENAL CELL CARCINOMA Reha-Baris Incesu, Lukas Scheipner, Simone Morra, Andrea Baudo, Carolin Siech, Letizia Maria Ippolita Jannello, Mario de Angelis, Anis Assad, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Alberto Briganti, Ottavio de Cobelli, Felix K. H. Chun, Luca Carmignani, Nicola Longo, Sascha Ahyai, Derya Tilki, Markus Graefen, and Pierre I. Karakiewicz Reha-Baris IncesuReha-Baris Incesu , Lukas ScheipnerLukas Scheipner , Simone MorraSimone Morra , Andrea BaudoAndrea Baudo , Carolin SiechCarolin Siech , Letizia Maria Ippolita JannelloLetizia Maria Ippolita Jannello , Mario de AngelisMario de Angelis , Anis AssadAnis Assad , Zhe TianZhe Tian , Fred SaadFred Saad , Shahrokh F. ShariatShahrokh F. Shariat , Alberto BrigantiAlberto Briganti , Ottavio de CobelliOttavio de Cobelli , Felix K. H. ChunFelix K. H. Chun , Luca CarmignaniLuca Carmignani , Nicola LongoNicola Longo , Sascha AhyaiSascha Ahyai , Derya TilkiDerya Tilki , Markus GraefenMarkus Graefen , and Pierre I. KarakiewiczPierre I. Karakiewicz View All Author Informationhttps://doi.org/10.1097/01.JU.0001008588.39303.c9.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: In metastatic clear-cell renal cell carcinoma (ccmRCC), sarcomatoid dedifferentiation is routinely reported in G4 patients, but routine reporting is not recommended in G3 patients. We tested independent predictor status of sarcomatoid dedifferentiation in G4 ccmRCC. Additionally, we explored whether sarcomatoid dedifferentiation may have a role in overall mortality (OM) prediction in G3 ccmRCC. METHODS: Within the Surveillance, Epidemiology, and End Results database, univariable and multivariable Cox-regression models assessed cytoreductive nephrectomy (CN)-treated ccmRCC patients (2010-2020). RESULTS: Of 2,644 CN-treated ccmRCC patients, 1,336 (51%) harbored G4, of whom 528 (40%) harbored sarcomatoid dedifferentiation. In G4, median overall survival (OS) according to presence vs. absence of sarcomatoid dedifferentiation was 20 vs. 21 months (p=0.6) and sarcomatoid dedifferentiation was not independent predictor in multivariable analyses. Of all, 1,308 (49%) harbored G3, of whom 79 (6%) harbored sarcomatoid dedifferentiation. In G3, median OS according to presence vs. absence of sarcomatoid dedifferentiation was 22 vs. 38 months (p<0.001) and sarcomatoid dedifferentiation independently predicted higher OM in multivariable analyses (hazard ratio 1.7, p<0.001). CONCLUSIONS: Reporting of sarcomatoid dedifferentiation in G4 RCC is routinely recommended. However, in G4 ccmRCC, presence of sarcomatoid dedifferentiation does not independently predict higher OM and its inclusion is not essential in multivariable considerations in G4 patients. Conversely, despite absence of standard reporting recommendation for sarcomatoid dedifferentiation in G3, presence of sarcomatoid dedifferentiation is associated with significantly higher mortality and achieved independent predictor status. Therefore, it possibly should be routinely reported and routinely included in multivariable analyses addressing G3 ccmRCC patients. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e140 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Reha-Baris Incesu More articles by this author Lukas Scheipner More articles by this author Simone Morra More articles by this author Andrea Baudo More articles by this author Carolin Siech More articles by this author Letizia Maria Ippolita Jannello More articles by this author Mario de Angelis More articles by this author Anis Assad More articles by this author Zhe Tian More articles by this author Fred Saad More articles by this author Shahrokh F. Shariat More articles by this author Alberto Briganti More articles by this author Ottavio de Cobelli More articles by this author Felix K. H. Chun More articles by this author Luca Carmignani More articles by this author Nicola Longo More articles by this author Sascha Ahyai More articles by this author Derya Tilki More articles by this author Markus Graefen More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement PDF downloadLoading ...