Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

Pillai et al. (Wed,) studied this question.

www.synapsesocial.com/papers/68e720ddb6db64358769aed9 — DOI: https://doi.org/10.1126/sciadv.adm9859

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis· 2013 · 2,176 citations
2. Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation· 2010 · 806 citations
3. Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection· 2007 · 2,112 citations
4. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen· 2020 · 534 citations
5. Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC· 2023 · 178 citations