Study of tert -butyl bromide hydrolysis in the 1-propanol/water system using the fundamental thermodynamic equation of chemical reactivity

Key Points

• The aim is to understand the hydrolysis of tert-butyl bromide in a specific solvent system using thermodynamic principles.
• Investigated hydrolysis in a 1-propanol and water binary solvent system.
• Applied the fundamental thermodynamic equation to analyze reactivity.
• Evaluated the transition state dynamics with a composition gradient.
• Identified key features of the transition state in the binary solvent.
• Suggested that composition gradients influence the solvation environment.

Abstract