P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.

Key Points

• This research aims to explore how P2X7R deficiency affects cardiac ageing, focusing on the role of the HuR/TRIM26/NR4A1 axis.
• Investigated the effects of P2X7R deficiency on cardiac tissues.
• Analyzed mitophagy markers related to cellular aging.
• Examined the HuR/TRIM26/NR4A1 signalling pathway for its regulatory role.
• P2X7R deficiency significantly enhances mitophagy in cardiac tissues.
• Activation of the HuR/TRIM26/NR4A1 axis is identified as crucial in improving cardiac health.
• Findings suggest a potential therapeutic target for cardiac ageing.

Abstract