Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke

Key Points

• The research aims to investigate the role of the IRF7-CXCL10 axis in microglial programmed cell death (PCD) during ischemic stroke.
• Conducted multi-omics analysis to examine the molecular pathways involved.
• Performed experimental validation of the identified pathway in vitro and in vivo.
• Utilized statistical methods to correlate findings with neuroinflammation levels.
• Identified IRF7 as a critical regulator of CXCL10 expression.
• Demonstrated that modulating the IRF7-CXCL10 axis impacts microglial PCD.
• Established a link between neuroinflammation and ischemic stroke outcomes.

Abstract