Pachyman Relieved the BPPV Progression in Slc26a4 loop/loop Mutant Mice Through Regulating the TLR2-mediated NF-κB Pathway

Key Points

• The research aims to evaluate the impact of pachyman on BPPV-related issues in a specific mouse model.
• Utilized Slc26a4 loop/loop mutant mice to assess vestibular deficits.
• Administered pachyman to determine its effect on BPPV progression.
• Analyzed changes in the TLR2-mediated NF-κB signaling pathway.
• Pachyman significantly improved vestibular function in mutant mice.
• Inhibition of the TLR2-mediated NF-κB pathway was observed following treatment with pachyman.

Abstract