What question did this study set out to answer?

This research aims to identify biomarker signatures related to host resistance and disease tolerance in sepsis.

April 10, 2026Open Access

Measuring signatures of host resistance, disease tolerance, and damage in human sepsis: a prospective cohort study

Key Points

This research aims to identify biomarker signatures related to host resistance and disease tolerance in sepsis.
Conducted a prospective cohort study.
Evaluated biomarker signatures informed by expert consensus.
Examined associations with clinical outcomes and sepsis subtypes.
Identified specific biomarker signatures associated with host resistance.
Demonstrated links between biomarker profiles and clinical outcomes in sepsis.
Found distinctions in biomarker signatures across different sepsis subtypes.

Abstract

Biomarker signatures aligned with host resistance to infection, disease tolerance, and damage to the host, informed by expert consensus, were associated with clinical outcomes and sepsis subtype membership.

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Discussion

Journals

Intensive Care Medicine

Institutions

University of Pittsburgh

University of Edinburgh

King's College London

References and Citations

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