Selective Serotonin Reuptake Inhibitor Treatment in Adolescence and Subsequent Risk of Nonaffective Psychosis: A Quasi‐Experimental Study

Key Points

• To examine whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescence is linked to later risk of nonaffective psychosis.
• Quasi-experimental design utilized to assess outcomes
• Examination of SSRIs as a treatment for common mental disorders (CMDs)
• Analysis of psychosis risk following SSRIs treatment during adolescence
• No evidence supporting a causal relationship between SSRIs and later psychosis risk
• Findings suggest SSRIs do not prevent later psychosis
• No significant differences observed in psychosis rates among treated and untreated individuals