Porous hydroxyapatite microparticles loaded with 169 Er for treatment of chronic inflammatory disease of small joints: harnessing mechanochemistry for synthesis of an advanced biomaterial

Key Points

• The aim is to develop nanoporous hydroxyapatite microparticles for treating chronic inflammatory diseases of small joints.
• Synthesis of HA microparticles using a solid-state mechanochemical approach.
• Utilization of a d(+)-glucose template for nanopore formation.
• Successful synthesis of nanoporous hydroxyapatite microparticles.
• Potential applicability of the developed biomaterial for targeted treatment.