Estrogen-induced epigenetic silencing of myotrophin reduces proliferation and is associated with chemosensitivity in hepatocellular carcinoma cells

Key Points

• The research aims to explore how estrogen affects myotrophin expression and its implications for hepatocellular carcinoma (HCC) growth and treatment sensitivity.
• Investigated the effects of estrogen on myotrophin expression in HCC cells.
• Analyzed the correlation between epigenetic changes and cell proliferation rates.
• Assessed chemosensitivity to doxorubicin (DOX) in treated cancer cells.
• Estrogen-induced silencing of myotrophin was observed.
• Reduced cell proliferation rates were linked to epigenetic repression.
• Enhanced chemosensitivity to DOX was associated with myotrophin silencing.

Abstract