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The study aims to evaluate microglial pathology in multiple sclerosis using PET imaging.

April 10, 2026Open Access

PET imaging of microglial pathology in multiple sclerosis

Key Points

The study aims to evaluate microglial pathology in multiple sclerosis using PET imaging.
Utilized PET imaging to assess brain inflammation in multiple sclerosis patients.
Compared findings with MRI results to determine detection capabilities of each method.
Evaluated glial responses to emerging neuroprotective therapies.
PET imaging identified inflammation that MRI could not detect.
Highlighted the role of microglial activity in the pathophysiology of MS.
Demonstrated potential for PET to guide therapeutic strategies in MS.

Abstract

Recent advances establish PET as an essential research tool for evaluating the presence of smouldering inflammation in MS brain not detectable using MRI. Furthermore, PET-based methods have proven suitable for measuring glial responses to potentially neuroprotective therapies currently under development.

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Authors

Olli Hartiala

Joel Tuomaala

Laura Airas

Journals

Current Opinion in Neurology

Actions

Institutions

University of Turku

Turku University Hospital

Center for Neurosciences

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PET imaging of microglial pathology in multiple sclerosis

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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