What question did this study set out to answer?

The aim is to highlight the importance of recognizing neurotrophic ulcers as potential indicators of serious underlying conditions.

April 15, 2026Open Access

Neurotrophic ulcer as the presenting symptom of central nervous system invasion in precursor B-cell lymphoblastic leukemia: a case report

Key Points

The aim is to highlight the importance of recognizing neurotrophic ulcers as potential indicators of serious underlying conditions.
Case report of a 33-year-old male with neurotrophic corneal ulcer.
Diagnostic work-up including MRI and magnetic resonance venography.
Cerebrospinal fluid analysis to investigate multiple cranial neuropathies.
Malignant cells were detected in the cerebrospinal fluid analysis.
Intrathecal chemotherapy was initiated following diagnosis.
Neurological symptoms included cranial nerve involvement on both sides.

Abstract

It is not uncommon that ophthalmologists encounter life-threatening conditions masquerading as common ocular complaints. We present a case of a 33-year-old male with neurotrophic corneal ulcer as the initial symptom of intracranial spread of precursor B-cell lymphoblastic leukemia. This was rapidly followed by affection of nerves VI, III on the right side, and II, VII on the left side. Work-up included MRI, magnetic resonance venography, and cerebrospinal fluid analysis to exclude various causes of multiple cranial neuropathies. Cerebrospinal fluid analysis revealed the presence of malignant cells, and intrathecal chemotherapy was initiated.

Neurotrophic ulcer as the presenting symptom of central nervous system invasion in precursor B-cell lymphoblastic leukemia: a case report

Key Points

Abstract

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