What question did this study set out to answer?

To explore how the REG Iα/EDNRB axis influences the malignant progression of colorectal cancer via Ca2+-dependent pathways.

April 15, 2026Open Access

Role of Ca 2+ ‐Dependent Epithelial‐Mesenchymal Transition in Malignant Progression of Colorectal Cancer: Special Focus on REG Iα/ EDNRB

Key Points

To explore how the REG Iα/EDNRB axis influences the malignant progression of colorectal cancer via Ca2+-dependent pathways.
Analysis of REG Iα and EDNRB interactions
Examination of epithelial-mesenchymal transition mechanisms
Investigation of Ca2+ signaling roles in colorectal cancer progression
Activation of Ca2+-dependent epithelial-mesenchymal transition indicates increased malignancy.
REG Iα/EDNRB axis significantly contributes to colorectal cancer metastasis.
Targeting this axis may offer new therapeutic strategies against colorectal cancer.

Abstract

The REG Iα/EDNRB axis promotes the malignant progression of CRC by activating Ca2+-dependent epithelial-mesenchymal transition, suggesting that targeting this axis is a promising therapeutic strategy to inhibit CRC metastasis.

Role of Ca 2+ ‐Dependent Epithelial‐Mesenchymal Transition in Malignant Progression of Colorectal Cancer: Special Focus on REG Iα/ EDNRB

Key Points

Abstract

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