Correction: Stimulation of Let-7 maturation by metformin improved the response to tyrosine kinase inhibitor therapy in an m6A dependent manner

PAGE \* 1 \* MERGEFORMAT 3In the published article, there was an error in Figure 1 and Figure 2 as published. We have identified an instance of unintentional incorrect usage of a Western blot image in our manuscript. After conducting an investigation, we confirmed that the original data was accurate and the Western blot results were correctly labeled and preserved. Therefore, we suspect that during the layout process, an error occurred where the original alternative image was mistakenly used in Figure 1D, while in the editing of Figure 2E-F, one Western blot band was not carefully discerned and was duplicated. The error occurred during the final stages of preparing the manuscript for publication, and despite our rigorous internal quality control measures, we regret that this oversight was not caught prior to the article's publication. We have conducted a comprehensive investigation to confirm that this was an isolated incident. We assure that all other figures and data within the article are accurate and reliable. Furthermore, we confirm that the erroneous selection of alternative images used for archiving purposes does not impact the scientific conclusions of the article. All the related raw data and original experimental results have been uploaded and archived for record-keeping purposes. The corrected Figure 1, Figure 2 and the captions appear below.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. A. Proliferation inhibitive ratios were detected for defining the Osimertinib resistant H1975OR cells and HCC827OR cells. B. The samples of lung Adenocarcinoma from TCGA data base (Pan-Cancer Atlas) were analyzed with mutation and CNA data, and Notch signaling participants were universally activated. C-D. Key functional factors of Notch signaling were primarily screened and confirmed by western blotting, and Notch signaling factors were overexpressed in resistant cells (The grouping of gels/blots were cropped from different parts, and the full-length gels could be referred to in the supplemental data). E. The inverse relationship between Let-7b and key Notch signaling activators was defining with using data from Star-Base Project. F. Let-7b decreased significantly in Osimertinib resistant H1975OR and HCC827OR cells (Fig. 2F).Figure 2 Notch signaling activation dependent stem cells renewal was responsible for Osimertinib resistance A-B. The ratio of ALDH1A1 (ALDH, ALDH1) positive cells accounted for less than 3% in H1975 and HCC827 cells, and Osimertinib decreased the ALDH1 positive stem cells ratio of H1975 and HCC827 effectively, however in H1975OR and HCC827OR cells, the ratios increased incredibly, and the stem cells ratio did not react to Osimertinib treatment. C. Proliferation inhibition ratio was essentially the same between H1975 cells and H1975OR cells, between HCC827 cells and HCC827OR cells. D. Let-7b decreased significantly in spheres of H1975 cells and HCC827 cells, and Osimertinib did not change the Let-7b expression comparing to the negative control. E-F. Stem cells were identified with overexpressed stem associated