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The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.
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Whitehouse et al. (Sat,) studied this question.
www.synapsesocial.com/papers/6a09df04b0d552aa8b45ed36 — DOI: https://doi.org/10.1002/ana.410100203
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
Peter J. Whitehouse
Donald L. Price
Arthur W. Clark
Annals of Neurology
Johns Hopkins University
Johns Hopkins Medicine
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