Figure S9 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8+ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Key Points

• MAIN FINDING: IGM-7354 significantly enhances the cytotoxicity of NK and CD8 T cells against PD-L1 positive tumor cells.
• KEY EVIDENCE: Increased proliferation and activation of NK cells was observed in a dose-dependent manner in humanized mice.
• APPROACH: The study utilized non-tumor bearing humanized mice to assess the effects of IGM-7354 on immune cells.
• SIGNIFICANCE: This research supports the potential use of IGM-7354 in cancer treatments by leveraging immune cell activity.

Abstract