Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8+ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Key Points

• IGM-7354 enhances cytotoxicity against PD-L1 positive tumor cells through NK and CD8+ T cell activation.
• Observations indicate significant binding properties of IGM-7354 related to PD-L1 and IL15.
• The approach involved examining the immunocytokine's effects in vitro on certain immune cells and tumor cells.
• Understanding IGM-7354's mechanism could lead to improved cancer therapies targeting PD-L1.

Abstract